Recent advances in the histo‐molecular pathology of human prion disease
Prion diseases are progressive neurodegenerative disorders affecting humans and other
mammalian species. The term prion, originally put forward to propose the concept that a …
mammalian species. The term prion, originally put forward to propose the concept that a …
Distinct types of amyloid‐β oligomers displaying diverse neurotoxicity mechanisms in Alzheimer's disease
P Madhu, S Mukhopadhyay - Journal of cellular biochemistry, 2021 - Wiley Online Library
Soluble oligomers of amyloid‐β (Aβ) are recognized as key pernicious species in
Alzheimer's disease (AD) that cause synaptic dysfunction and memory impairments …
Alzheimer's disease (AD) that cause synaptic dysfunction and memory impairments …
The cellular prion protein increases the uptake and toxicity of TDP-43 fibrils
Cytoplasmic aggregation of the primarily nuclear TAR DNA-binding protein 43 (TDP-43)
affects neurons in most amyotrophic lateral sclerosis (ALS) and approximately half of …
affects neurons in most amyotrophic lateral sclerosis (ALS) and approximately half of …
Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy
AS König, NS Rösener, L Gremer, M Tusche… - Journal of Biological …, 2021 - ASBMB
Human PrP (huPrP) is a high-affinity receptor for oligomeric amyloid β (Aβ) protein
aggregates. Binding of Aβ oligomers to membrane-anchored huPrP has been suggested to …
aggregates. Binding of Aβ oligomers to membrane-anchored huPrP has been suggested to …
Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease
The cellular prion protein (PrP C) can act as a cell-surface receptor for β-amyloid (Aβ)
peptide; however, a role for PrP C in the pathogenesis of Alzheimer's disease (AD) is …
peptide; however, a role for PrP C in the pathogenesis of Alzheimer's disease (AD) is …
Proteopathic seed amplification assays for neurodegenerative disorders
N do Carmo Ferreira… - Clinics in laboratory …, 2020 - labmed.theclinics.com
In order to function properly, proteins typically must fold and assume defined native three-
dimensional structures. However, disruption of native protein folding may allow abnormal …
dimensional structures. However, disruption of native protein folding may allow abnormal …
Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation
J Ezpeleta, V Baudouin, ZE Arellano-Anaya… - Nature …, 2019 - nature.com
The presence of amyloid beta (Aβ) plaques in the brain of some individuals with Creutzfeldt-
Jakob or Gertsmann-Straussler-Scheinker diseases suggests that pathogenic prions …
Jakob or Gertsmann-Straussler-Scheinker diseases suggests that pathogenic prions …
The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins
M Rossi, H Kai, S Baiardi, A Bartoletti-Stella… - Acta neuropathologica …, 2019 - Springer
Current evidence indicating a role of the human prion protein (PrP) in amyloid-beta (Aβ)
formation or a synergistic effect between Aβ and prion pathology remains controversial …
formation or a synergistic effect between Aβ and prion pathology remains controversial …
Infectious prions do not induce Aβ deposition in an in vivo seeding model
J Rasmussen, S Krasemann, H Altmeppen… - Acta …, 2018 - Springer
An increasing number of studies have suggested that certain cases of iatrogenic Creutzfeldt–
Jakob disease (iCJD) that harbor significant β-amyloid (Aβ) pathology are the result of …
Jakob disease (iCJD) that harbor significant β-amyloid (Aβ) pathology are the result of …
Adaptación de un sistema de propagación de priones in vitro para el cribado masivo de compuestos específicos frente a las encefalopatías espongiformes …
E González Miranda - 2020 - ekoizpen-zientifikoa.ehu.eus
Las Encefalopatías Espongiformes Transmisibles (EET) son un conjunto de desórdenes
neurodegenerativos mortales que afectan a varios mamíferos incluidos los humanos, cuyo …
neurodegenerativos mortales que afectan a varios mamíferos incluidos los humanos, cuyo …