Infections at the maternal–fetal interface: an overview of pathogenesis and defence

CJ Megli, CB Coyne - Nature Reviews Microbiology, 2022 - nature.com
Infections are a major threat to human reproductive health, and infections in pregnancy can
cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to …

Chagas disease in the United States: a public health approach

C Bern, LA Messenger, JD Whitman… - Clinical microbiology …, 2019 - Am Soc Microbiol
Trypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by
triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal …

Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

[HTML][HTML] Congenital Chagas disease: an update

Y Carlier, S Sosa-Estani, AO Luquetti… - Memorias do Instituto …, 2015 - SciELO Brasil
Congenital infection with Trypanosoma cruzi is a global problem, occurring on average in
5% of children born from chronically infected mothers in endemic areas, with variations …

Chagas disease:“the new HIV/AIDS of the Americas”

PJ Hotez, E Dumonteil, L Woc-Colburn… - PLoS neglected …, 2012 - journals.plos.org
Endemic Chagas disease has emerged as an important health disparity in the Americas. As
a result, we face a situation in both Latin America and the US that bears a resemblance to …

Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects

E Dumonteil, ME Bottazzi, B Zhan… - Expert review of …, 2012 - Taylor & Francis
Chagas disease is a leading cause of heart disease affecting approximately 10 million
people in Latin America and elsewhere worldwide. The two major drugs available for the …

[HTML][HTML] Congenital Chagas disease as an ecological model of interactions between Trypanosoma cruzi parasites, pregnant women, placenta and fetuses

Y Carlier, C Truyens - Acta Tropica, 2015 - Elsevier
The aim of this paper is to discuss the main ecological interactions between the parasite
Trypanosoma cruzi and its hosts, the mother and the fetus, leading to the transmission and …

Chagas' disease: pregnancy and congenital transmission

AM Cevallos, R Hernández - BioMed research international, 2014 - Wiley Online Library
Chagas disease is a chronic infection that kills approximately 12,000 people a year. Mass
migration of chronically infected and asymptomatic persons has caused globalization of …

Putting infection dynamics at the heart of Chagas disease

MD Lewis, JM Kelly - Trends in parasitology, 2016 - cell.com
In chronic Trypanosoma cruzi infections, parasite burden is controlled by effective, but
nonsterilising immune responses. Infected cells are difficult to detect because they are …

Challenges and perspectives of Chagas disease: a review

PCM Pereira, EC Navarro - Journal of venomous animals and toxins …, 2013 - SciELO Brasil
Chagas disease (CD), also known as American trypanosomiasis, is caused by the
flagellated protozoan Trypanosoma cruzi, and affects an estimated 8 to 10 million people …