Castration-resistant prostate cancer (CRPC) is a lethal stage of disease in which androgen
receptor (AR) signaling is persistent despite androgen deprivation therapy (ADT). Most …

Prostate cancer is the most common cancer in aging men. Despite recent progress, there
are still few effective treatments to cure its aggressive and metastatic stages. A better …

Simple Summary As many cancers, prostate cancer is lethal when reaching the metastatic
state. Starting from prostate to invade secondary sites, tumour cells undergo structural …

Abstract Background and Aims The tumor microenvironment (TME) exerts an important role
in carcinogenesis and progression. Several investigations have suggested that immune cell …

Androgen deprivation therapy (ADT) is the front-line treatment for early and metastatic
prostate cancer, and the development of tumor resistance to it has major clinical …