Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Electrospray ionization mass spectrometry has been used to study protein interactions
driven by noncovalent forces. The gentleness of the electrospray ionization process allows …

Epigenetic modifications mainly includes nucleic modifications and histone modifications,
which play crucial role in biological processes, such as gene and microRNA expression …

This is a review of work pertaining to noncovalent binding interactions involving primarily the
cationic guanidinium group and the anionic sulf [on] ate and phosph [on] ate groups. 1 To a …

Electrospray ionization mass spectrometry (ESI-MS) has demonstrated utility for the
detection and study of weakly bound, noncovalent complexes, including protein interactions …

For a number of years, soft ionization mass spectrometry has been used for studying
noncovalently bound complexes. An intriguing question in this context is whether MS …

For many years, analytical mass spectrometry has had numerous supporting roles in the
drug development process, including the assessment of compound purity; quantitation of …

Electrospray ionization (ESI) mass spectrometry (MS) is a crucial method for rapidly
determining the interactions between small molecules and proteins with ultrahigh sensitivity …

The initial stages of drug discovery are increasingly reliant on development and
improvement of analytical methods to investigate protein–protein and protein–ligand …

We report a method based on electrospray ionization (ESI) mass spectrometry to determine
solution association constants (KA) for complexes between glycopeptide antibiotics …