Single molecule force spectroscopy is a powerful method that uses the mechanical
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …

Highlights•Studying biomolecular folding with optical tweezers grants high dynamic
range.•Combining optical tweezers with molecular dynamics simulation enables accurate …

There is a wide range of applications for non-covalent DNA binding ligands, and
optimization of such interactions requires detailed understanding of the binding …

In this review we focus on the idea of establishing connections between the mechanical
properties of DNA–ligand complexes and the physical chemistry of DNA–ligand interactions …

The binding properties between psoralen (PSO) and calf thymus DNA (ctDNA) were
predicted by molecular docking, and then determined with the use of UV–vis absorption …

We use optical tweezers to perform stretching experiments on DNA molecules when
interacting with the drugs daunomycin and ethidium bromide, which intercalate the DNA …

A theoretical treatment of optical tweezers is presented at a level suitable for
undergraduates. We explore the Rayleigh and the geometrical optics regimes with an …

Since most therapeutic efforts have been predominantly focused on pharmaceuticals that
target proteins, there is an unmet need to develop drugs that intercept cellular pathways that …

Optical tweezers have become powerful tools to manipulate biomolecular systems, but are
increasingly difficult to use when the size of the molecules is< 1 μm. Many important …

The mechanism of the [2+ 2] cycloaddition photoreaction of psoralen and a DNA
nucleobase, thymine, cornerstone of the furocoumarin-based PUVA (psoralen+ UVA …