Biophysical characterization of DNA binding from single molecule force measurements
KR Chaurasiya, T Paramanathan, MJ McCauley… - Physics of life …, 2010 - Elsevier
Single molecule force spectroscopy is a powerful method that uses the mechanical
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …
[HTML][HTML] Optical tweezers for drug discovery
Highlights•Studying biomolecular folding with optical tweezers grants high dynamic
range.•Combining optical tweezers with molecular dynamics simulation enables accurate …
range.•Combining optical tweezers with molecular dynamics simulation enables accurate …
Mechanisms of small molecule–DNA interactions probed by single-molecule force spectroscopy
AA Almaqwashi, T Paramanathan… - Nucleic acids …, 2016 - academic.oup.com
There is a wide range of applications for non-covalent DNA binding ligands, and
optimization of such interactions requires detailed understanding of the binding …
optimization of such interactions requires detailed understanding of the binding …
Extracting physical chemistry from mechanics: a new approach to investigate DNA interactions with drugs and proteins in single molecule experiments
MS Rocha - Integrative Biology, 2015 - academic.oup.com
In this review we focus on the idea of establishing connections between the mechanical
properties of DNA–ligand complexes and the physical chemistry of DNA–ligand interactions …
properties of DNA–ligand complexes and the physical chemistry of DNA–ligand interactions …
Probing the binding mode of psoralen to calf thymus DNA
X Zhou, G Zhang, L Wang - International journal of biological …, 2014 - Elsevier
The binding properties between psoralen (PSO) and calf thymus DNA (ctDNA) were
predicted by molecular docking, and then determined with the use of UV–vis absorption …
predicted by molecular docking, and then determined with the use of UV–vis absorption …
Transition on the entropic elasticity of DNA induced by intercalating molecules
MS Rocha, MC Ferreira, ON Mesquita - The Journal of chemical …, 2007 - pubs.aip.org
We use optical tweezers to perform stretching experiments on DNA molecules when
interacting with the drugs daunomycin and ethidium bromide, which intercalate the DNA …
interacting with the drugs daunomycin and ethidium bromide, which intercalate the DNA …
Optical tweezers for undergraduates: theoretical analysis and experiments
MS Rocha - American Journal of Physics, 2009 - pubs.aip.org
A theoretical treatment of optical tweezers is presented at a level suitable for
undergraduates. We explore the Rayleigh and the geometrical optics regimes with an …
undergraduates. We explore the Rayleigh and the geometrical optics regimes with an …
[图书][B] Methods for studying nucleic acid/drug interactions
Since most therapeutic efforts have been predominantly focused on pharmaceuticals that
target proteins, there is an unmet need to develop drugs that intercept cellular pathways that …
target proteins, there is an unmet need to develop drugs that intercept cellular pathways that …
[HTML][HTML] Stretching submicron biomolecules with constant-force axial optical tweezers
Optical tweezers have become powerful tools to manipulate biomolecular systems, but are
increasingly difficult to use when the size of the molecules is< 1 μm. Many important …
increasingly difficult to use when the size of the molecules is< 1 μm. Many important …
Photoreactivity of furocoumarins and DNA in PUVA therapy: formation of psoralen− thymine adducts
JJ Serrano-Pérez, M Merchan… - The Journal of Physical …, 2008 - ACS Publications
The mechanism of the [2+ 2] cycloaddition photoreaction of psoralen and a DNA
nucleobase, thymine, cornerstone of the furocoumarin-based PUVA (psoralen+ UVA …
nucleobase, thymine, cornerstone of the furocoumarin-based PUVA (psoralen+ UVA …