Initial diagnostic workup of acute leukemia: guideline from the College of American Pathologists and the American Society of Hematology

DA Arber, MJ Borowitz, M Cessna… - … of pathology & …, 2017 - meridian.allenpress.com
Context.—A complete diagnosis of acute leukemia requires knowledge of clinical
information combined with morphologic evaluation, immunophenotyping and karyotype …

Post-mortem whole-exome analysis in a large sudden infant death syndrome cohort with a focus on cardiovascular and metabolic genetic diseases

J Neubauer, MR Lecca, G Russo, C Bartsch… - European Journal of …, 2017 - nature.com
Sudden infant death syndrome (SIDS) is described as the sudden and unexplained death of
an apparently healthy infant younger than one year of age. Genetic studies indicate that up …

[HTML][HTML] Comparison of methods for the extraction of DNA from formalin-fixed, paraffin-embedded archival tissues

B Sengüven, E Baris, T Oygur… - International journal of …, 2014 - ncbi.nlm.nih.gov
Aim: Discussing a protocol involving xylene-ethanol deparaffinization on slides followed by
a kit-based extraction that allows for the extraction of high quality DNA from FFPE tissues …

Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens

SE Yost, EN Smith, RB Schwab, L Bao… - Nucleic acids …, 2012 - academic.oup.com
The utilization of archived, formalin-fixed paraffin-embedded (FFPE) tumor samples for
massive parallel sequencing has been challenging due to DNA damage and contamination …

Robust gene expression and mutation analyses of RNA-sequencing of formalin-fixed diagnostic tumor samples

S Graw, R Meier, K Minn, C Bloomer, AK Godwin… - Scientific reports, 2015 - nature.com
Current genomic studies are limited by the availability of fresh tissue samples. Here, we
show that Illumina RNA sequencing of formalin-fixed diagnostic tumor samples produces …

Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis

SJ Kim, P Cheresh, RP Jablonski… - … of Physiology-Lung …, 2020 - journals.physiology.org
Alveolar epithelial cell (AEC) apoptosis, arising from mitochondrial dysfunction and
mitophagy defects, is important in mediating idiopathic pulmonary fibrosis (IPF). Our group …

Thymoquinone protects the testes of hypothyroid rats by suppressing pro-inflammatory cytokines and oxidative stress and promoting SIRT1 testicular expression

SA Algaidi, KA Faddladdeen, GI Alrefaei… - Frontiers in …, 2022 - frontiersin.org
Background: Hypothyroidism has been linked to many testicular structural and dysfunctional
changes in males. Thymoquinone (TQ) has shown a potent testicular protective effect …

[HTML][HTML] Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics

S Munchel, Y Hoang, Y Zhao, J Cottrell, B Klotzle… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Current genomic studies are limited by the poor availability of fresh-frozen tissue samples.
Although formalin-fixed diagnostic samples are in abundance, they are seldom used in …

Molecular investigation of possible relationships concerning bovine leukemia virus and breast cancer

Z Khan, M Abubakar, MJ Arshed, R Aslam, S Sattar… - Scientific reports, 2022 - nature.com
Worldwide, breast cancer has an eminent morbidity and mortality rate, as it is a neoplastic
disease among females. The query of the prospective danger of bovine leukemia virus …

[HTML][HTML] Data resources for the identification and interpretation of actionable mutations by clinicians

A Prawira, TJ Pugh, TL Stockley, LL Siu - Annals of Oncology, 2017 - Elsevier
Following initial characterization of the reference human genome, initiatives have evolved
worldwide to identify genomic aberrations in cancer with the aim of deriving diagnostic …