The central nervous system is not a static, hard-wired organ. Examples of neuroplasticity,
whether at the level of the synapse, the cell, or within and between circuits, can be found …

Over the past century, robust methods were developed that enable the isolation, culture, and
dynamic observation of mammalian neuronal networks in vitro. But even if neuronal culture …

Directed differentiation of human pluripotent stem cells (hPSCs) into somatic counterparts is
a valuable tool for studying disease. However, examination of developmental mechanisms …

Much of Alzheimer disease (AD) research has been traditionally based on the use of
animals, which have been extensively applied in an effort to both improve our understanding …

Neurons obtained directly from human somatic cells hold great promise for disease
modeling and drug screening. Available protocols rely on overexpression of transcription …

The Mitochondrial Human Proteome Project aims at understanding the function of the
mitochondrial proteome and its crosstalk with the proteome of other organelles. Being able …

Mutations in presenilin (PSEN) 1 and 2, which encode components of the γ-secretase (GS)
complex, cause familial Alzheimer's disease (FAD). It is hypothesized that altered GS …

Animal models of Alzheimer's disease (AD) have been extensively utilized for decades in an
effort to elucidate the pathophysiological mechanisms of this disease and to test novel …

Spinal cord injuries and motor neuron-related disorders impact on life of many patients
around the world. Since pharmacotherapy and surgical approaches were not efficient to …

The technology to convert adult human non-neural cells into neural lineages, through
induced pluripotent stem cells (iPSCs), somatic cell nuclear transfer, and direct lineage …