Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized
mice, have become increasingly important as small, preclinical animal models for the study …

The study of human-specific infectious agents has been hindered by the lack of optimal
small animal models. More recently development of novel strains of immunodeficient mice …

Objective Our aim was to assess the real‐world effectiveness of immune checkpoint
inhibitors for treatment of patients with progressive multifocal leukoencephalopathy (PML) …

JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system
demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML …

Model animals naturally differ from humans in various respects and results from the former
are not directly translatable to the latter. One approach to address this issue is humanized …

Progressive multifocal leukoencephalopathy (PML) is a rare, but serious, complication
encountered in patients treated with a select number of disease-modifying therapies (DMTs) …

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease triggered by
infection with the human gliotropic JC virus (JCV). Due to the human-selective nature of the …

The pathogenesis of infectious agents with human tropism can only be properly studied in
an in vivo model featuring human cells or tissue. Humanized mice represent a small animal …

Liver sinusoidal endothelial cells (LSECs) are specialized scavenger cells that mediate high-
capacity clearance of soluble waste macromolecules and colloid material, including blood …

The human fetal glial cell line SVG was generated in 1985 by transfecting primary fetal brain
cells with a plasmid containing an origin-defective mutant of simian virus 40 (SV40). The …