Cancer is the leading cause of death worldwide, and its treatment and outcomes have been
dramatically revolutionised by targeted therapies. As the most frequently mutated oncogene …

Lung cancer is the leading cause of cancer death in Canada and a significant cause of
morbidity for patients and their loved ones. There have been rapid advances in preventing …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to
therapy,. This is mediated in part by a complex tumour microenvironment, low vascularity …

Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …

Immune checkpoint inhibitors (ICIs) have revolutionized the clinical management of multiple
tumours. However, only a few patients respond to ICIs, which has generated considerable …

The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell
growth and facilitate tumor development. Glucose and glutamine in the TME are essential for …

Oncogenic Kras-activated pancreatic ductal adenocarcinoma (PDAC) cells highly rely on an
unconventional glutamine catabolic pathway to sustain cell growth. However, little is known …

Background: Lung adenocarcinoma (LUAD), the major subtype of lung cancer, is among the
leading cause of cancer-related death worldwide. Energy-related metabolic reprogramming …

Mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) is part of the malate-aspartate
shuttle, a mechanism by which cells transfer reducing equivalents from the cytosol to the …