The existence of mitogen activated protein kinases (MAPKs) in platelets has been known for
more than 20 years. Since that time hundreds of reports have been published describing the …

Metabolic syndrome combines major risk factors for cardiovascular disease, making deeper
insight into its pathogenesis important. We here explore the mechanistic basis of metabolic …

Cell-free heme (CFH) is a product of hemoglobin, myoglobin and hemoprotein degradation,
which is a hallmark of pathologies associated with extensive hemolysis and tissue damage …

Platelet activation plays a key role in cardiovascular diseases. The generation of
mitochondrial reactive oxygen species (ROS) has been described as a critical step required …

Safety has always been an important issue affecting the development of traditional Chinese
medicine industry, especially for toxic medicinal materials, the establishment of risk …

Mitochondria play a crucial role in cellular metabolism and bioenergetics, orchestrating
various cellular processes, including energy production, metabolism, adaptation to stress …

This study was focused on investigating the anticancer potential of indole-3-carbinol (I3C)
against lung cancer H1299 cells via an increase in ROS levels. To investigate the induction …

Treatment of hematologic malignancies is a formidable challenge for hematologists and
there is an urgent need to identify safe and efficacious agents either via synthesis in the …

Platelet apoptosis is irreversible under current storage conditions in blood banks. Studies
have shown that programmed cell death ligand 1 (PD-L1) in tumour cells is required for …

Comprehensive proteomic analyses of human and murine platelets established an
extraordinary intracellular repertoire of signaling components, which control crucial …