The translation of messenger RNA (mRNA) into protein and the folding of the resulting
protein into an active form are prerequisites for virtually every cellular process and represent …

Translation is one of the fundamental processes of life. It comprises the assembly of
polypeptides whose amino acid sequence corresponds to the codon sequence of an …

Transfer RNA (tRNA) molecules are sumptuously decorated with evolutionary conserved
post-transcriptional nucleoside modifications that are essential for structural stability and …

Global protein translation as well as translation at the codon level can be regulated by tRNA
modifications. In eukaryotes, levels of tRNA queuosinylation reflect the bioavailability of the …

RNA methylations are essential both for RNA structure and function, and are introduced by a
number of distinct methyltransferases (MTases). In recent years, N 6-methyladenosine …

The epitranscriptome has emerged as a new fundamental layer of control of gene
expression. Nevertheless, the determination of the transcriptome-wide occupancy and …

Fungal pathogens threaten ecosystems and human health. Understanding the molecular
basis of their virulence is key to develop new treatment strategies. Here, we characterize …

Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and
thereby plays a key role in protein synthesis. Human eEF1A is subject to extensive post …

Abstract m6A is the most abundant internal modification in eukaryotic mRNA. It is introduced
by METTL3‐METTL14 and tunes mRNA metabolism, impacting cell differentiation and …

Ribosome profiling measures genome-wide translation dynamics at sub-codon resolution.
Cycloheximide (CHX), a widely used translation inhibitor to arrest ribosomes in these …