Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

Midbrain dopamine (DA) neurons are proposed to signal reward prediction error (RPE), a
fundamental parameter in associative learning models. This RPE hypothesis provides a …

The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that
addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 …

Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate
receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 …

Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in
various therapeutic applications from pain to epilepsy, but its psychotropic effect has …

Drug-evoked synaptic plasticity in the mesolimbic system reshapes circuit function and
drives drug-adaptive behavior. Much research has focused on excitatory transmission in the …

Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic
transmission throughout the central nervous system. Accordingly, eCBs are involved in …

The mechanisms subserving the ability of glucocorticoid signaling within the medial
prefrontal cortex (mPFC) to terminate stress-induced activation of the hypothalamic–pituitary …

Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that
controls neural circuits involved in the cognitive, emotional, and motor aspects of goal …

Long-lasting changes of brain function in response to experience rely on diverse forms of
activity-dependent synaptic plasticity. Chief among them are long-term potentiation and long …