The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

The advent of direct-acting antivirals (DAAs) has brought about a sudden renaissance in the
treatment of chronic hepatitis C virus (HCV) infection with SVR rates now routinely> 90 …

Hepatitis C virus infection is a major health problem worldwide and no vaccine has yet been
developed against this virus. In addition, currently approved pharmacotherapies achieve …

Background & Aims Direct-acting antivirals that target nonstructural protein 5A (NS5A), such
as daclatasvir, have high potency against the hepatitis C virus (HCV). They are promising …

Hepatitis C Virus (HCV) infects over 150 million people worldwide. In most cases HCV
infection becomes chronic, causing liver disease ranging from fibrosis to cirrhosis and …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …

Some direct-acting antiviral agents for hepatitis C virus (HCV), such as telaprevir and
boceprevir have been available since 2011. It was reported that HCV NS5A is associated …

Highlights•HCV NS5A replication complex inhibitors.•Exceptional potency with broad
genotype coverage translated in clinical studies.•Important component for HCV combination …

Objective To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with
pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin. Design In this Phase …

Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also
uses direct cell-cell transfer to infect neighboring hepatocytes. Viral cell-cell transmission …