Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …

Background The exciting discovery that telomere shortening is associated with many health
conditions and that telomere lengths can be altered in response to social and environmental …

Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …

The generation of reactive oxygen species (ROS) is a fundamental aspect of normal human
biology. However, when ROS generation exceeds endogenous antioxidant capacity …

Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …

Cellular senescence, defined as arrest during the cell cycle (G0), is involved in the complex
process of the biological ageing of tissues, organs, and organisms. Senescence is driven by …

Understanding the malleable determinants of cellular aging is critical to understanding
human longevity. Telomeres may provide a pathway for exploring this question. Telomeres …

The telomere length of replicating somatic cells is inversely correlated with age and has
been reported to be associated cross-sectionally with cardiovascular disease (CVD) …

Background Telomeres play a key role in the maintenance of chromosome integrity and
stability, and telomere shortening is involved in initiation and progression of malignancies. A …