Most adaption processes have a polygenic genetic basis, but even with the recent explosive
growth of genomic data we are still lacking a unified framework describing the dynamics of …

Advances in the sequencing and the analysis of the genomes of both modern and ancient
peoples have facilitated a number of breakthroughs in our understanding of human …

Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

The key regulators of the transcriptional response to hypoxia and inflammation (hypoxia
inducible factor, HIF, and nuclear factor-kappa B, NF-κB, respectively) are evolutionarily …

As modern humans migrated out of Africa, they encountered many new environmental
conditions, including greater temperature extremes, different pathogens and higher …

High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

Cattle domestication and the complex histories of East Asian cattle breeds warrant further
investigation. Through analysing the genomes of 49 modern breeds and eight East Asian …

Genomics is a relatively new scientific discipline, having DNA sequencing as its core
technology. As technology has improved the cost and scale of genome characterization over …

The spread of modern humans across the globe has led to genetic adaptations to diverse
local environments. Recent developments in genomic technologies, statistical analyses, and …

Local-ancestry inference is an important step in the genetic analysis of fully sequenced
human genomes. Current methods can only detect continental-level ancestry (ie, European …