Although they were discovered more than 50 years ago, caveolae have remained enigmatic
plasmalemmal organelles. With their characteristic “flasklike” shape and virtually ubiquitous …

Genetic information flows from DNA to macromolecular structures—the dominant force in the
molecular organization of life. However, recent work suggests that metabolite availability to …

The caveolin gene family has three members in vertebrates: caveolin-1, caveolin-2, and
caveolin-3. So far, most caveolin-related research has been conducted in mammals, but the …

EGF receptor (EGFR) overexpression correlates with metastasis in a variety of carcinomas,
but the underlying mechanisms are poorly understood. We demonstrated that EGF disrupted …

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling
organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most …

Caveolae are 50-to 100-nm omega-shaped invaginations of the plasma membrane that
function as regulators of signal transduction. Caveolins are a class of oligomeric structural …

N-Glycan branching in the medial-Golgi generates ligands for lattice-forming lectins (eg,
galectins) that regulate surface levels of glycoproteins including epidermal growth factor …

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

Abstract The AAA-ATPase VCP (also known as p97) cooperates with distinct cofactors to
process ubiquitylated proteins in different cellular pathways,,. VCP missense mutations …

Caveolae are vesicular organelles (50—100‐nm in diameter) that are particularly abundant
in cells of the cardiovascular system, including endothelial cells, smooth muscle cells …