Loss-of-function genetic tools for animal models: cross-species and cross-platform differences
BE Housden, M Muhar, M Gemberling… - Nature Reviews …, 2017 - nature.com
Our understanding of the genetic mechanisms that underlie biological processes has relied
extensively on loss-of-function (LOF) analyses. LOF methods target DNA, RNA or protein to …
extensively on loss-of-function (LOF) analyses. LOF methods target DNA, RNA or protein to …
Development of a new screening system for the identification of RNF43-related genes and characterisation of other PA-RING family members.
A Merenda - 2017 - repository.cam.ac.uk
The E3 ubiquitin ligase RNF43 (RING finger protein 43) is an important negative modulator
of the WNT signalling pathway that acts at the plasma membrane by targeting Frizzled and …
of the WNT signalling pathway that acts at the plasma membrane by targeting Frizzled and …