Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …

Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Individual free fatty acids (FAs) play important roles in metabolic homeostasis, many through
engagement with more than 40G protein–coupled receptors. Searching for receptors to …

Designer receptors exclusively activated by designer drugs (DREADDs) represent a
powerful chemogenetic technology for the remote control of neuronal activity and cellular …

The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not
only pain but also addiction and affective disorders. However, the development of KOR …

Despite the increasing number of GPCR structures and recent advances in peptide design,
the development of efficient technologies allowing rational design of high-affinity peptide …

The skin, including the hypodermis, is the largest body organ and is in constant contact with
the environment. Neurogenic inflammation is the result of the activity of nerve endings and …

Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins,
are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty …

Opioids are used for pain management despite the side effects that contribute to the opioid
crisis. The pursuit of non-addictive opioid analgesics remains unattained due to the …

The human MAS-related G protein–coupled receptor X1 (MRGPRX1) is preferentially
expressed in the small-diameter primary sensory neurons and involved in the mediation of …