Macrophages are cells of the innate immune system that regulate the maintenance of tissue
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …

The peroxisome proliferator-activated receptor (PPAR) family includes three transcription
factors: PPARα, PPARβ/δ, and PPARγ. PPAR are nuclear receptors activated by oxidised …

Background & Aims Nearly 20% of the global cancer burden can be linked to infectious
agents. Fusobacterium nucleatum promotes tumor formation by epithelial cells via unclear …

Monocytes and macrophages provide defence against pathogens and danger signals.
These cells respond to stimulation in a fast and stimulus-specific manner by utilizing …

Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in
organisms ranging from slime molds to mammals. Central to their function is their ability to …

Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …

NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis
and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn …

Over the past few years, several groups have identified new genes that are transcriptionally
induced downstream of type I interferon (IFN) signalling and that inhibit infection by …

Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …

Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects
genes controlling vital processes. Among them, the peroxisome proliferator-activated …