Spinal cord injury: molecular mechanisms and therapeutic interventions
X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …
The challenges of SCI repair include its complex pathological mechanisms and the …
[HTML][HTML] Beyond activation: characterizing microglial functional phenotypes
J Lier, WJ Streit, I Bechmann - Cells, 2021 - mdpi.com
Classically, the following three morphological states of microglia have been defined:
ramified, amoeboid and phagocytic. While ramified cells were long regarded as “resting” …
ramified, amoeboid and phagocytic. While ramified cells were long regarded as “resting” …
Three-dimensional-cultured MSC-derived exosome-hydrogel hybrid microneedle array patch for spinal cord repair
M Han, H Yang, X Lu, Y Li, Z Liu, F Li, Z Shang… - Nano …, 2022 - ACS Publications
Exosomes derived from mesenchymal stem cells (MSCs) have been proven to exhibit great
potentials in spinal cord injury (SCI) therapy. However, conventional two-dimensional (2D) …
potentials in spinal cord injury (SCI) therapy. However, conventional two-dimensional (2D) …
Robust and multifunctional nanoparticles assembled from natural polyphenols and metformin for efficient spinal cord regeneration
The treatment of spinal cord injury (SCI) remains unsatisfactory owing to the complex
pathophysiological microenvironments at the injury site and the limited regenerative …
pathophysiological microenvironments at the injury site and the limited regenerative …
Carrier-free nanodrug based on Co-assembly of methylprednisolone dimer and rutin for combined treatment of spinal cord injury
H Wang, F Lin, Y Wu, W Guo, X Chen, C Xiao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …
and accumulation of oxidative substance, would severely impede neurological functional …
Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway
M Ge, H Tian, L Mao, D Li, J Lin, H Hu… - CNS Neuroscience …, 2021 - Wiley Online Library
Aim Spinal cord injury (SCI) involves multiple pathological processes. Ferroptosis has been
shown to play a critical role in the injury process. We wanted to explore whether zinc can …
shown to play a critical role in the injury process. We wanted to explore whether zinc can …
Inflammation: a target for treatment in spinal cord injury
X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …
Emergency treatment and photoacoustic assessment of spinal cord injury using reversible dual‐signal transform‐based selenium antioxidant
Spinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and
irreversible pathological deterioration of the central nervous system. Thus, preventing …
irreversible pathological deterioration of the central nervous system. Thus, preventing …
Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury
I Francos-Quijorna, M Sánchez-Petidier… - Nature …, 2022 - nature.com
Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and
neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical …
neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical …
Allicin, an antioxidant and neuroprotective agent, ameliorates cognitive impairment
Allicin (diallylthiosulfinate) is a defense molecule produced by cellular contents of garlic
(Allium sativum L.). On tissue damage, the non-proteinogenic amino acid alliin (S …
(Allium sativum L.). On tissue damage, the non-proteinogenic amino acid alliin (S …