Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

[HTML][HTML] Beyond activation: characterizing microglial functional phenotypes

J Lier, WJ Streit, I Bechmann - Cells, 2021 - mdpi.com
Classically, the following three morphological states of microglia have been defined:
ramified, amoeboid and phagocytic. While ramified cells were long regarded as “resting” …

Three-dimensional-cultured MSC-derived exosome-hydrogel hybrid microneedle array patch for spinal cord repair

M Han, H Yang, X Lu, Y Li, Z Liu, F Li, Z Shang… - Nano …, 2022 - ACS Publications
Exosomes derived from mesenchymal stem cells (MSCs) have been proven to exhibit great
potentials in spinal cord injury (SCI) therapy. However, conventional two-dimensional (2D) …

Robust and multifunctional nanoparticles assembled from natural polyphenols and metformin for efficient spinal cord regeneration

T Yuan, T Wang, J Zhang, P Liu, J Xu, Z Gu, J Xu, Y Li - ACS nano, 2023 - ACS Publications
The treatment of spinal cord injury (SCI) remains unsatisfactory owing to the complex
pathophysiological microenvironments at the injury site and the limited regenerative …

Carrier-free nanodrug based on Co-assembly of methylprednisolone dimer and rutin for combined treatment of spinal cord injury

H Wang, F Lin, Y Wu, W Guo, X Chen, C Xiao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …

Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway

M Ge, H Tian, L Mao, D Li, J Lin, H Hu… - CNS Neuroscience …, 2021 - Wiley Online Library
Aim Spinal cord injury (SCI) involves multiple pathological processes. Ferroptosis has been
shown to play a critical role in the injury process. We wanted to explore whether zinc can …

Inflammation: a target for treatment in spinal cord injury

X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Emergency treatment and photoacoustic assessment of spinal cord injury using reversible dual‐signal transform‐based selenium antioxidant

Z Ji, J Zheng, Y Ma, H Lei, W Lin, J Huang, H Yang… - Small, 2023 - Wiley Online Library
Spinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and
irreversible pathological deterioration of the central nervous system. Thus, preventing …

Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury

I Francos-Quijorna, M Sánchez-Petidier… - Nature …, 2022 - nature.com
Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and
neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical …

Allicin, an antioxidant and neuroprotective agent, ameliorates cognitive impairment

MS Nadeem, I Kazmi, I Ullah, K Muhammad, F Anwar - Antioxidants, 2021 - mdpi.com
Allicin (diallylthiosulfinate) is a defense molecule produced by cellular contents of garlic
(Allium sativum L.). On tissue damage, the non-proteinogenic amino acid alliin (S …