Euphorbia diterpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)
Z Zhan, S Li, W Chu, S Yin - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2013 to 2021 As the characteristic metabolites of Euphorbia plants, Euphorbia
diterpenoids have always been a hot topic in related science communities due to their …
diterpenoids have always been a hot topic in related science communities due to their …
[HTML][HTML] Metal-and metalloid-based compounds to target and reverse cancer multidrug resistance
Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …
stage of the disease. However, based on their versatile chemistry, metal and metalloid …
[HTML][HTML] Galangin (GG) combined with cisplatin (DDP) to suppress human lung cancer by inhibition of STAT3-regulated NF-κB and Bcl-2/Bax signaling pathways
S Yu, L Gong, N Li, Y Pan, L Zhang - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Lung cancer represents a significant problem for public health worldwide. Galangin (GG), a
natural active compound 3, 5, 7-trihydroxyflavone, is a type of bioflavonoid, which is isolated …
natural active compound 3, 5, 7-trihydroxyflavone, is a type of bioflavonoid, which is isolated …
Jatrophane and rearranged jatrophane-type diterpenes: Biogenesis, structure, isolation, biological activity and SARs (1984–2019)
Diterpene compounds specially macrocyclic ones comprising jatrophane, lathyrane,
terracinolide, ingenane, pepluane, paraliane, and segetane skeletons occurring in plants of …
terracinolide, ingenane, pepluane, paraliane, and segetane skeletons occurring in plants of …
Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles
Multidrug resistance (MDR) is a serious obstacle to efficient cancer treatment.
Overexpression of P-glycoprotein (P-gp) plays a significant role in MDR. Recent studies …
Overexpression of P-glycoprotein (P-gp) plays a significant role in MDR. Recent studies …
Dual inhibitors as a new challenge for cancer multidrug resistance treatment
T Stanković, J Dinić, A Podolski-Renić… - Current Medicinal …, 2019 - ingentaconnect.com
Background: Dual-targeting in cancer treatment by a single drug is an unconventional
approach in relation to drug combinations. The rationale for the development of …
approach in relation to drug combinations. The rationale for the development of …
Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells
V Lopes-Rodrigues, A Di Luca, D Sousa, H Seca… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Background Multidrug resistance (MDR) is a serious impediment to cancer treatment, with
overexpression of drug efflux pumps such as P-glycoprotein (P-gp) playing a significant role …
overexpression of drug efflux pumps such as P-glycoprotein (P-gp) playing a significant role …
A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells
V Lopes-Rodrigues, A Oliveira… - Bioorganic & Medicinal …, 2017 - Elsevier
Cancer multidrug resistance (MDR) is a major limitation to the success of cancer treatment
and is highly associated with the overexpression of drug efflux pumps such as P …
and is highly associated with the overexpression of drug efflux pumps such as P …
L-amino acid oxidase from snake venom: Biotransformation and induction of apoptosis in human colon cancer cells
DD Nikodijević, JV Jovankić, DM Cvetković… - European Journal of …, 2021 - Elsevier
This study evaluated the potential of antitumor activity of snake venom from Vipera
ammodytes and L-amino acid oxidase from Crotalus adamanteus on different colorectal …
ammodytes and L-amino acid oxidase from Crotalus adamanteus on different colorectal …
New approaches with natural product drugs for overcoming multidrug resistance in cancer
J Dinic, A Podolski-Renic, T Stankovic… - Current …, 2015 - ingentaconnect.com
Resistance to chemotherapeautic drugs is one of the main obstacles to effective cancer
treatment. Multidrug resistance (MDR) is defined as resistance to structurally and/or …
treatment. Multidrug resistance (MDR) is defined as resistance to structurally and/or …