Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Cerebrovascular dysfunction significantly contributes to the clinical presentation and
pathoetiology of Alzheimer's disease (AD). Deposition and aggregation of β-amyloid (Aβ) …

Background We assessed the impact of retinoid X receptor (RXR) agonist bexarotene on
brain amyloid measured by amyloid imaging in patients with Alzheimer's disease (AD) in a …

Amyloid-(A) clearance from brain, which is decreased in Alzheimer's disease, is facilitated
by apolipoprotein E (ApoE). ApoE is upregulated by activation of the retinoid X receptor …

The retinoid X receptors (RXRs) are ligand-activated transcription factors involved in, for
example, differentiation and apoptosis regulation. Currently used reference RXR agonists …

Previous data demonstrate that bexarotene (Bex), retinoid X receptor (RXR) agonist,
reduces soluble and insoluble amyloid-β (Aβ) in Alzheimer disease (AD)-transgenic mice …

Background Bexarotene is a synthetic retinoid from the subclass of retinoids called rexinoids
which selectively activate retinoid X receptors. It has activity in cutaneous T‐cell lymphoma …

Obesity and metabolic disorders are of great societal concern and generate substantial
human health care costs globally. Interventions have resulted in only minimal impacts on …

Treatment with the second and third generation BCR-ABL1 tyrosine kinase inhibitors (TKIs)
increases cardiovascular risk in chronic myeloid leukemia (CML) patients. We investigated …

The three retinoid X receptor subtypes (RXRα, RXRβ, RXRγ) exhibit critical regulatory roles
in cell proliferation and differentiation, metabolism, and inflammation. Due to their …