Enzymes can be engineered at the level of their amino acid sequences to optimize key
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …

Protein evolution or engineering studies are traditionally focused on amino acid
substitutions and the way these contribute to fitness. Meanwhile, the insertion and deletion …

In recent years, generative protein sequence models have been developed to sample novel
sequences. However, predicting whether generated proteins will fold and function remains …

The improved production, recycling, and removal of plastic waste, such as polyethylene
terephthalate (PET), are pressing environmental and economic issues for society …

Pathogens secrete effector proteins to subvert host physiology and cause disease. Effectors
are engaged in a molecular arms race with the host resulting in conflicting evolutionary …

Insertions and deletions constitute the second most important source of natural genomic
variation. Insertions and deletions make up to 25% of genomic variants in humans and are …

The reconstruction of ancestral sequences can offer a glimpse into the fascinating process of
molecular evolution by exposing the adaptive pathways that shape the proteins found in …

Prunella vulgaris is one of the bestselling and widely used medicinal herbs. It is recorded as
an ace medicine for cleansing and protecting the liver in Chinese Pharmacopoeia and has …

Selective, one‐step C− H activation of fatty acids from biomass is an attractive concept in
sustainable chemistry. Biocatalysis has shown promise for generating high‐value hydroxy …

Motivation Insertions and deletions (indels) influence the genetic code in fundamentally
distinct ways from substitutions, significantly impacting gene product structure and function …