The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

In the last decades, autoimmune diseases have experienced a dramatic increase in Western
countries. The involvement of environmental factors is strongly suspected to explain this rise …

Obesity is a risk factor for various cardiovascular diseases including hypertension,
atherosclerosis, and myocardial infarction. Recent studies aimed at understanding the …

Circulating levels of adiponectin (APN) are reduced in obesity and associated comorbidities,
with inflammation playing an important role in downregulating APN production. In contrast to …

Inflammation is widely known to play a key role in the development and progression of
cardiovascular diseases. It is becoming increasingly evident that obesity is linked to many …

The metabolism of healthy murine and more recently human immune cells has been
investigated with an increasing amount of details. These studies have revealed the …

Over the past few decades, our understanding of the role of adipose tissue has changed
dramatically. Far from simply being a site of energy storage or a modulator of the endocrine …

Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune
system attacks its own tissues and organs. However, the causes of SLE remain unknown …

Abstract T helper 17 (Th17) cells are vital components of the adaptive immune system
involved in the pathogenesis of most autoimmune and inflammatory syndromes, and …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by
multisystem organ involvement and unclear pathogenesis. Several adipokines synthesized …