Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues, including
adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate …

The small heat shock protein Hsp27 or its murine homologue Hsp25 acts as an ATP-
independent chaperone in protein folding, but is also implicated in architecture of the …

1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …

Worldwide, the prevalence of obesity and diabetes have increased, with heart disease being
their leading cause of death. Traditionally, the management of obesity and diabetes has …

As the most metabolically demanding organ in the body, the heart must generate massive
amounts of energy adenosine triphosphate (ATP) from the oxidation of fatty acids …

Ninety percent of plasma fatty acids (FAs) are contained within lipoprotein-triglyceride, and
lipoprotein lipase (LPL) is robustly expressed in the heart. Hence, LPL-mediated lipolysis of …

Observations of Golgi fragmentation upon introduction of G protein βγ (Gβγ) subunits into
cells have implicated Gβγ in a pathway controlling the fission at the trans-Golgi network …

Proper regulation of LPL is important for controlling the delivery of lipid nutrients to tissues.
Recent studies have identified GPIHBP1 as the molecule that transports LPL to the capillary …

Background Lipoprotein lipase (LPL)‐derived fatty acid is a major source of energy for
cardiac contraction. Synthesized in cardiomyocytes, LPL requires translocation to the …

Obesity causes a range of tissue dysfunctions that increases the risk for morbidity and
mortality. Protein kinase D (PKD) represents a family of stress-activated intracellular …