ATP-dependent chromatin remodeling during mammalian development
SK Hota, BG Bruneau - Development, 2016 - journals.biologists.com
Precise gene expression ensures proper stem and progenitor cell differentiation, lineage
commitment and organogenesis during mammalian development. ATP-dependent …
commitment and organogenesis during mammalian development. ATP-dependent …
Genetic regulation of vertebrate forebrain development by homeobox genes
Forebrain development in vertebrates is regulated by transcription factors encoded by
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …
Genomic analyses implicate noncoding de novo variants in congenital heart disease
A genetic etiology is identified for one-third of patients with congenital heart disease (CHD),
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …
PRC2 facilitates the regulatory topology required for poised enhancer function during pluripotent stem cell differentiation
S Cruz-Molina, P Respuela, C Tebartz, P Kolovos… - Cell stem cell, 2017 - cell.com
Poised enhancers marked by H3K27me3 in pluripotent stem cells have been implicated in
the establishment of somatic expression programs during embryonic stem cell (ESC) …
the establishment of somatic expression programs during embryonic stem cell (ESC) …
Early patterning and specification of cardiac progenitors in gastrulating mesoderm
Mammalian heart development requires precise allocation of cardiac progenitors. The
existence of a multipotent progenitor for all anatomic and cellular components of the heart …
existence of a multipotent progenitor for all anatomic and cellular components of the heart …
Transcriptional networks controlled by NKX2-1 in the development of forebrain GABAergic neurons
M Sandberg, P Flandin, S Silberberg, L Su-Feher… - Neuron, 2016 - cell.com
The embryonic basal ganglia generates multiple projection neurons and interneuron
subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors …
subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors …
Genome-wide transcriptional regulation mediated by biochemically distinct SWI/SNF complexes
Multiple positions within the SWI/SNF chromatin remodeling complex can be filled by
mutually exclusive subunits. Inclusion or exclusion of these proteins defines many unique …
mutually exclusive subunits. Inclusion or exclusion of these proteins defines many unique …
Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment
Sequencing studies have implicated haploinsufficiency of ARID1B, a SWI/SNF chromatin-
remodeling subunit, in short stature (Yu et al., 2015), autism spectrum disorder (O'Roak et …
remodeling subunit, in short stature (Yu et al., 2015), autism spectrum disorder (O'Roak et …
Tissue-specific RNA expression marks distant-acting developmental enhancers
H Wu, AS Nord, JA Akiyama, M Shoukry, V Afzal… - PLoS …, 2014 - journals.plos.org
Short non-coding transcripts can be transcribed from distant-acting transcriptional enhancer
loci, but the prevalence of such enhancer RNAs (eRNAs) within the transcriptome, and the …
loci, but the prevalence of such enhancer RNAs (eRNAs) within the transcriptome, and the …
Chromatin remodelers and lineage-specific factors interact to target enhancers to establish proneurosensory fate within otic ectoderm
J Xu, J Li, T Zhang, H Jiang… - Proceedings of the …, 2021 - National Acad Sciences
Specification of Sox2+ proneurosensory progenitors within otic ectoderm is a prerequisite for
the production of sensory cells and neurons for hearing. However, the underlying molecular …
the production of sensory cells and neurons for hearing. However, the underlying molecular …