In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …

Protection of chromosome ends from DNA repair and degradation activities is mediated by
specialized protein complexes bound to telomere repeats. Recently, it has become apparent …

The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and …

Drosophila telomeres comprise DNA sequences that differ dramatically from those of other
eukaryotes. Telomere functions, however, are similar to those found in telomerase‐based …

Signaling of chromosomal DNA breaks is of primary importance for initiation of repair and,
thus, for global genomic stability. Although the Mre11-Rad50-Nbs1 (MRN) complex is the …

LKB1 and AMP-activated protein kinase (AMPK) are serine–threonine kinases implicated in
key cellular pathways, including polarity establishment and energy sensing, respectively …

Abstract During mitosis, the phosphatidylinositol‐3 (PI‐3) family‐related DNA damage
checkpoint kinases ATM and ATR were found on the centrosomes of human cells. ATRIP, an …

The maintenance of genome integrity through generations is largely determined by the
stability of telomeres. Increasing evidence suggests that telomere dysfunction may trigger …

The maintenance of chromosome ends in Drosophila is an exceptional phenomenon
because it relies on the transposition of specialized retrotransposons rather than on the …

Transposons and other selfish DNA elements can be found in all phyla, and mobilization of
these elements can compromise genome integrity. The piRNA (PIWI-interacting RNA) …