The transcription factor p53 is an important regulator of a multitude of cellular processes. In
the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest …

To discover and develop novel natural compounds, active ingredients, single herbs and
combination formulas or prescriptions in traditional Chinese medicine (TCM) with …

Despite being the subject of extensive research and clinical trials, neuroblastoma remains a
major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard …

Proteasome-mediated degradation is a common mechanism by which cells renew their
intracellular proteins and maintain protein homeostasis. In this process, the E3 ubiquitin …

Breast cancer is the primary cause of cancer death in women. Although current therapies
have shown some promise against breast cancer, there is still no effective cure for the …

The p53 tumor suppressor plays a major role in controlling the initiation and development of
cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 …

The prognosis of patients with ovarian cancer has remained poor mainly because of
aggressive cancer progression. Since epithelial-mesenchymal transition (EMT) is an …

Abstract Ethnopharmacological relevance Panax notoginseng (Burkill) FH Chen
(Araliaceae) has been extensively used as a therapeutic agent to treat a variety of diseases …

A requirement for Mouse Double Minute 2 (MDM2) oncogene activation has been
suggested to be associated with cancer progression and metastasis, including breast …

Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …