Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches
MS Uddin, A Al Mamun, BS Alghamdi, D Tewari… - Seminars in cancer …, 2022 - Elsevier
Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …
Paediatric and adult glioblastoma: multiform (epi) genomic culprits emerge
We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
[HTML][HTML] Pan-cancer landscape of aberrant DNA methylation across human tumors
The discovery of cancer-associated alterations has primarily focused on genetic variants.
Nonetheless, altered epigenomes contribute to deregulate transcription and promote …
Nonetheless, altered epigenomes contribute to deregulate transcription and promote …
The 2007 WHO classification of tumours of the central nervous system
DN Louis, H Ohgaki, OD Wiestler, WK Cavenee… - Acta …, 2007 - Springer
The fourth edition of the World Health Organization (WHO) classification of tumours of the
central nervous system, published in 2007, lists several new entities, including angiocentric …
central nervous system, published in 2007, lists several new entities, including angiocentric …
Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography
C Kut, KL Chaichana, J Xi, SM Raza, X Ye… - Science translational …, 2015 - science.org
More complete brain cancer resection can prolong survival and delay recurrence. However,
it is challenging to distinguish cancer from noncancer tissues intraoperatively, especially at …
it is challenging to distinguish cancer from noncancer tissues intraoperatively, especially at …
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics
Tumourigenesis and cancer progression require enhanced global protein translation,–.
Such enhanced translation is caused by oncogenic and tumour-suppressive events that …
Such enhanced translation is caused by oncogenic and tumour-suppressive events that …
Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice
Background Cell proliferation in all rapidly renewing mammalian tissues follows a circadian
rhythm that is often disrupted in advanced-stage tumors. Epidemiologic studies have …
rhythm that is often disrupted in advanced-stage tumors. Epidemiologic studies have …
DNA methylation in glioblastoma: impact on gene expression and clinical outcome
Background Changes in promoter DNA methylation pattern of genes involved in key
biological pathways have been reported in glioblastoma. Genome-wide assessments of …
biological pathways have been reported in glioblastoma. Genome-wide assessments of …
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer
O Aguilera, MF Fraga, E Ballestar, MF Paz, M Herranz… - Oncogene, 2006 - nature.com
Colorectal cancer is a major cause of cancer death worldwide. A number of key oncogenes
and tumor suppressor genes have been proposed to drive progression from healthy colonic …
and tumor suppressor genes have been proposed to drive progression from healthy colonic …
Prognosis Analysis and Validation of m6A Signature and Tumor Immune Microenvironment in Glioma
Glioma is one of the most typical intracranial tumors, comprising about 80% of all brain
malignancies. Several key molecular signatures have emerged as prognostic biomarkers …
malignancies. Several key molecular signatures have emerged as prognostic biomarkers …