▪ Abstract This review describes the three mammalian glutathione transferase (GST)
families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated …

Considerable support exists for the roles of metabolism in modulating the carcinogenic
properties of chemicals. In particular, many of these compounds are pro-carcinogens that …

Glutathione (GSH) and related enzymes are pivotal for the normal functioning of several
important biological processes. In this review we discuss the biosynthesis and the catalytic …

Sumach (Rhus coriaria L.) is widely used as a spice. The aim of this study was the
investigation of its DNA-protective effects in humans and animals. Prevention of the …

Polycyclic aromatic hydrocarbons (PAHs) are associated with occupational exposure and
urban atmospheric pollution. Determination of the genotoxic properties of these compounds …

Catalytic promiscuity is a widespread, but poorly understood, phenomenon among enzymes
with particular relevance to the evolution of new functions, drug metabolism, and in vitro …

The structurally related glutathione S-transferase isoforms GSTA1-1 and GSTA4-4 differ
greatly in their relative catalytic promiscuity. GSTA1-1 is a highly promiscuous detoxification …

Abstract Benzo (a) pyrene (BaP) is a representative polycyclic aromatic hydrocarbon (PAH)
compound, which has been implicated in cancer initiation and promotion. Although BaP is …

The lung is an organ that is sensitive to mutations induced by chemicals in ambient air, and
transgenic mice harboring guanine phosphoribosyltransferase (gpt) gene as a target gene …

A general description of effects of toxic compounds in mammalian cells is facing several
problems. Firstly, most toxic compounds are hydrophobic and partition phenomena strongly …