Large-scale mapping studies have identified 236 independent genetic variants associated
with an increased risk of multiple sclerosis. However, none of these variants are found …

Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by
massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions …

The rapid and efficient phagocytic clearance of apoptotic cells, termed efferocytosis, is a
critical mechanism in the maintenance of tissue homeostasis. Removal of apoptotic cells …

Multiple sclerosis is a complex neurological disease, with∼ 20% of risk heritability
attributable to common genetic variants, including> 230 identified by genome-wide …

Increasing evidence suggests that pathogenic mechanisms underlying neurodegeneration
are strongly linked with neuroinflammatory responses. Tyro3, Axl, and Mertk (TAM receptors) …

Abstract Tyro3, Axl, and Mertk, referred to as the TAM family of receptor tyrosine kinases, are
instrumental in maintaining cell survival and homeostasis in mammals. TAM receptors …

Objective: To document functional differences between monocyte-derived macrophages
(MDMs) of patients with MS and the ability of age/sex-matched healthy donor cells to …

Macrophages engulf and destroy pathogens (phagocytosis) and apoptotic cells
(efferocytosis), and can subsequently initiate adaptive immune responses by presenting …

Abstract Tyro3, Axl and Mertk are members of the TAM family of tyrosine kinase receptors.
TAMs are activated by two structurally homologous ligands GAS6 and PROS1. TAM …

Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of
which are mediated by the interaction with three transmembrane tyrosine kinase receptors …