Genetics of multiple sclerosis: lessons from polygenicity
A Goris, M Vandebergh, JL McCauley… - The Lancet …, 2022 - thelancet.com
Large-scale mapping studies have identified 236 independent genetic variants associated
with an increased risk of multiple sclerosis. However, none of these variants are found …
with an increased risk of multiple sclerosis. However, none of these variants are found …
[HTML][HTML] The physiology of foamy phagocytes in multiple sclerosis
E Grajchen, JJA Hendriks, JFJ Bogie - Acta neuropathologica …, 2018 - Springer
Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by
massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions …
massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions …
[HTML][HTML] Cellular responses to the efferocytosis of apoptotic cells
The rapid and efficient phagocytic clearance of apoptotic cells, termed efferocytosis, is a
critical mechanism in the maintenance of tissue homeostasis. Removal of apoptotic cells …
critical mechanism in the maintenance of tissue homeostasis. Removal of apoptotic cells …
[HTML][HTML] Low-frequency and rare-coding variation contributes to multiple sclerosis risk
M Mitrovič, NA Patsopoulos, AH Beecham… - Cell, 2018 - cell.com
Multiple sclerosis is a complex neurological disease, with∼ 20% of risk heritability
attributable to common genetic variants, including> 230 identified by genome-wide …
attributable to common genetic variants, including> 230 identified by genome-wide …
TAM receptor pathways at the crossroads of neuroinflammation and neurodegeneration
Increasing evidence suggests that pathogenic mechanisms underlying neurodegeneration
are strongly linked with neuroinflammatory responses. Tyro3, Axl, and Mertk (TAM receptors) …
are strongly linked with neuroinflammatory responses. Tyro3, Axl, and Mertk (TAM receptors) …
The role of TAM family receptors and ligands in the nervous system: from development to pathobiology
Abstract Tyro3, Axl, and Mertk, referred to as the TAM family of receptor tyrosine kinases, are
instrumental in maintaining cell survival and homeostasis in mammals. TAM receptors …
instrumental in maintaining cell survival and homeostasis in mammals. TAM receptors …
MerTK-mediated regulation of myelin phagocytosis by macrophages generated from patients with MS
LM Healy, JH Jang, SY Won, YH Lin… - Neurology …, 2017 - AAN Enterprises
Objective: To document functional differences between monocyte-derived macrophages
(MDMs) of patients with MS and the ability of age/sex-matched healthy donor cells to …
(MDMs) of patients with MS and the ability of age/sex-matched healthy donor cells to …
[HTML][HTML] Rab17 mediates differential antigen sorting following efferocytosis and phagocytosis
Macrophages engulf and destroy pathogens (phagocytosis) and apoptotic cells
(efferocytosis), and can subsequently initiate adaptive immune responses by presenting …
(efferocytosis), and can subsequently initiate adaptive immune responses by presenting …
[HTML][HTML] TAM signaling in the nervous system
T Burstyn-Cohen, A Hochberg - Brain Plasticity, 2021 - content.iospress.com
Abstract Tyro3, Axl and Mertk are members of the TAM family of tyrosine kinase receptors.
TAMs are activated by two structurally homologous ligands GAS6 and PROS1. TAM …
TAMs are activated by two structurally homologous ligands GAS6 and PROS1. TAM …
[HTML][HTML] The Gas6/TAM system and multiple sclerosis
M Bellan, M Pirisi, PP Sainaghi - International Journal of Molecular …, 2016 - mdpi.com
Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of
which are mediated by the interaction with three transmembrane tyrosine kinase receptors …
which are mediated by the interaction with three transmembrane tyrosine kinase receptors …