Peptides as a therapeutic modality attract much attention due to their synthetic accessibility,
high degree of specific binding, and the ability to target protein surfaces traditionally …

Drug discovery has traditionally focused on using libraries of small molecules to identify
therapeutic drugs, but new modalities, especially libraries of genetically encoded cyclic …

Backbone macrocyclic structures are often found in diverse bioactive peptides and
contribute to greater conformational rigidity, peptidase resistance, and potential membrane …

Lentiviral vectors (LVs) have been widely used as a tool for gene therapies. However, tissue-
selective transduction after systemic delivery remains a challenge. Inducible degrader of low …

The budding of HIV from infected cells is driven by the protein–protein interaction between
the p6 domain of the HIV Gag protein and the UEV domain of the human TSG101 protein …

The root of Platycodon grandiflorum (PG) has long been used as a traditional herbal
medicine in Asian country. Platycondin D (PD), triterpenoid saponin that is a main …

The E3 ubiquitin ligase inducible degrader of the LDL recept... : Current Opinion in
Lipidology The E3 ubiquitin ligase inducible degrader of the LDL receptor/myosin light …

Cyclic peptides discovered by genetically encoded library technologies have emerged as a
class of promising molecules in chemical biology and drug discovery. Here we review the …

Hyperlipidemia is one of the main risk factors that contributed to atherosclerosis and
coronary artery disease (CAD). In the present study, our objective was to explore whether …

With the increasing utilization of high-throughput screening for lead identification in drug
discovery, the need for easily constructed and diverse libraries which cover significant …