Fe–S clusters are partners in the origin of life that predate cells, acetyl-CoA metabolism,
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …

In a murine model, we have linked early life toxicant exposure to reduced uterine sensitivity
to progesterone, a phenotype we had previously associated with inflammation in …

UVA radiation (320–400 nm) is a major environmental agent that can exert its deleterious
action on living organisms through absorption of the UVA photons by endogenous or …

In mammalian cells, active ribosomal genes produce the 18S, 5.8 S and 28S RNAs of
ribosomal particles. Transcription levels of these genes are very high throughout interphase …

MacroH2A has been linked to transcriptional silencing, cell identity, and is a hallmark of the
inactive X chromosome (Xi). However, it remains unclear whether macroH2A plays a role in …

The eukaryotic DNA replication fork is a hub of enzymes that continuously act to synthesize
DNA, propagate DNA methylation and other epigenetic marks, perform quality control, repair …

The replication of the genome is a highly organized process, both spatially and temporally.
Although a lot is known on the composition of the basic replication machinery, how its …

Chromatin has been shown to undergo diffusional motion, which is affected during gene
transcription by RNA polymerase activity. However, the relationship between chromatin …

The multiplication of cells in all living organisms requires a tight regulation of DNA
replication. Several mechanisms take place to ensure that the DNA is replicated faithfully …

Although several studies have suggested that the functions of heterochromatin regulators
may be regulated by post-translational modifications during cell cycle progression …