A pervasive view is that undifferentiated stem cells are alone responsible for generating all
other cells and are the origins of cancer. However, emerging evidence demonstrates fully …

Terminally differentiated cells need never replicate their genomes and may therefore
dispense with the daunting task of maintaining several repair systems to constantly scan …

This review will examine the known and postulated relationships between nucleotide
excision repair (NER) and neurological diseases. We will begin with a description of NER …

Simple Summary The sun is a deadly laser, and its damaging rays harm exposed tissues
such as our skin and eyes. The skin's protection and repair mechanisms are well understood …

Human embryonic stem cells (hESCs) tend to lose genomic integrity during long periods of
culture in vitro and to acquire a cancer-like phenotype. In this study, we aim at …

To protect genomic integrity living cells that are continuously exposed to DNA-damaging
insults are equipped with an efficient defence mechanism termed the DNA damage …

Nucleotide excision repair (NER), which is arguably the most versatile DNA repair system, is
strongly attenuated in human cells of the monocytic lineage when they differentiate into …

This report was prepared by a task group of International Commission on Radiological
Protection (ICRP) Committee 1 under the following terms of reference:(a) to review stem cell …

Simple Summary Ultraviolet light from the sun causes DNA damage and is a major
exogenous genotoxin, particularly affecting the skin and eyes of humans. UV-induced …

DNA repair is a double‐edged sword in stem cells. It protects normal stem cells in both
embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact …