Repressor element-1 silencing transcription factor (REST) or also known as neuron-
restrictive silencing factor (NRSF), is the key initiator of epigenetic neuronal gene …

We have developed an efficient approach to generate functional induced dopaminergic (DA)
neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of …

Extreme stress is closely linked with symptoms of depression. Chronic social stress can
cause structural and functional changes in the brain. These changes are associated with …

Background Astrocytes have been demonstrated to undergo conversion into functional
neurons, presenting a promising approach for stroke treatment. However, the development …

Summary The microRNA (miRNA) miR-124 has been employed supplementary to
neurogenic transcription factors (TFs) and other miRNAs to enhance direct neurogenic …

Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by
forced expression of transcription factors. The generated neurons can be used for both cell …

Glial progenitor cells are widely distributed in brain parenchyma and represent a suitable
target for future therapeutic interventions that generate new neurons via in situ …

Neurons produced by reprogramming of other cell types are used to study cellular
mechanisms of age-related neurodegenerative diseases. To model Alzheimer's disease and …

Mitochondrial diseases are a heterogeneous group of rare genetic disorders that can be
caused by mutations in nuclear (nDNA) or mitochondrial DNA (mtDNA). Mutations in mtDNA …

Mesencephalic dopaminergic (mDA) neurons derived from pluripotent stem cells (PSCs)
have proven to be pivotal for disease modeling studies and as a source of transplantable …