1, 3, 5‐Triazine: A versatile pharmacophore with diverse biological activities

S Singh, MK Mandal, A Masih, A Saha… - Archiv der …, 2021 - Wiley Online Library
Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to
their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer …

Privileged S-Triazines: Structure and Pharmacological Applications

DR Shah, RP Modh, KH Chikhalia - Future medicinal chemistry, 2014 - Taylor & Francis
This review summarizes recent reports on s-triazine and its respective analogs from the
medicinal chemistry angle. Due to its high reactivity and binding characteristic towards …

Exploration and Evaluation of Secondary Metabolites from Trichoderma harzianum: GC-MS Analysis, Phytochemical Profiling, Antifungal and Antioxidant Activity …

W Lakhdari, I Benyahia, MM Bouhenna, H Bendif… - Molecules, 2023 - mdpi.com
In this study, we investigated in vitro the potential of Trichoderma harzianum to produce
bioactive secondary metabolites that can be used as alternatives to synthetic compounds …

New heterocyclic hybrids of pyrazole and its bioisosteres: Design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents

AA Bekhit, AMM Hassan, HA Abd El Razik… - European journal of …, 2015 - Elsevier
A new series of pyrazole derivatives were synthesized by hybridization with five-membered
heterocyclic moieties such as thiazoles, thiazolidinones, 1, 3, 4-thiadiazoles and …

Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents

E Jameel, P Meena, M Maqbool, J Kumar… - European journal of …, 2017 - Elsevier
In our endeavor towards the development of potent multitarget ligands for the treatment of
Alzheimer's disease, a series of triazine-triazolopyrimidine hybrids were designed …

Design and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating Epidermal Growth Factor Receptor tyrosine kinase

JK Srivastava, GG Pillai, HR Bhat, A Verma… - Scientific Reports, 2017 - nature.com
A novel series of hybrid analogues of monastrol-1, 3, 5-triazine were designed and
developed via one-pot synthesis using Bi (NO3) 3 as a catalyst. Entire compounds were …

A novel of azo-thiazole moiety alternative for benzidine-based pigments: design, synthesis, characterization, biological evaluation, and molecular docking study

HF Rizk, MA El-Borai, A Ragab… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A new series of coloring compounds (pigments) based on 5-(2-aminothiazol-5-yl) thiazol-2-
amine and 5-(4-aminophenyl) thiazol-2-amine as heterocyclic alternatives for benzidine …

Chimeric Tobramycin-Based Adjuvant TOB-TOB-CIP Potentiates Fluoroquinolone and β-Lactam Antibiotics against Multidrug-Resistant Pseudomonas aeruginosa

S Dhiman, D Ramirez, Y Li, A Kumar… - ACS Infectious …, 2023 - ACS Publications
According to the World Health Organization, antibiotic resistance is a global health threat. Of
particular importance are infections caused by multidrug-resistant Gram-negative bacteria …

Discovery of novel 1, 3, 5-triazine derivatives as potent inhibitor of cervical cancer via dual inhibition of PI3K/mTOR

J Hu, Y Zhang, N Tang, Y Lu, P Guo, Z Huang - Bioorganic & Medicinal …, 2021 - Elsevier
This study describes the synthesis of novel 1, 3, 5-triazine derivatives as potent inhibitors of
cervical cancer. The compounds were initially tested for inhibition of PI3K/mTOR, where they …

Folate metabolism in human malaria parasites—75 years on

IB Müller, JE Hyde - Molecular and biochemical parasitology, 2013 - Elsevier
Malaria still poses one of the most serious threats to human health worldwide and the
prevailing lack of effective, clinically licensed, vaccines means that prophylaxis and …