Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …

Heart valves control unidirectional blood flow within the heart during the cardiac cycle. They
have a remarkable ability to withstand the demanding mechanical environment of the heart …

Induced corneal collagen crosslinking and mechanical stiffening via ultraviolet-A
photoactivation of riboflavin (UVA CXL) is now a common treatment for corneal ectasia and …

Purpose: Collagen is the main load-bearing component of the eye, and collagen crimp is a
critical determinant of tissue mechanical behavior. We test the hypothesis that collagen …

Purpose: To test the hypothesis that human, monkey, pig, sheep, cow, and goat eyes exhibit
circumferential, radial, and interweaving collagen architecture in the posterior sclera …

The rhythmic electrical activity of the heart's natural pacemaker, the sinoatrial node (SAN),
determines cardiac beating rate (BR). SAN electrical activity is tightly controlled by multiple …

Our goal was to quantify and characterize how the collagen fiber crimp waviness of the
lamina cribrosa (LC) and peripapillary sclera (PPS) changes with intraocular pressure (IOP) …

Assessment of mitral valve (MV) function is important in many diagnostic, prognostic, and
surgical planning applications for treatment of MV disease. Yet, to date, there are no …

Heterogeneities in structure and stress within heart valve leaflets are of significant concern
to their functional physiology, as they affect how the tissue constituents remodel in response …

Purpose: Although collagen microstructural crimp is a major determinant of ocular
biomechanics, no direct measurements of optic nerve head (ONH) crimp have been …