TBX5: a key regulator of heart development
JD Steimle, IP Moskowitz - Current topics in developmental biology, 2017 - Elsevier
TBX5 is a member of the T-box transcription factor family and is primarily known for its role in
cardiac and forelimb development. Human patients with dominant mutations in TBX5 are …
cardiac and forelimb development. Human patients with dominant mutations in TBX5 are …
Overview of high throughput sequencing technologies to elucidate molecular pathways in cardiovascular diseases
High throughput sequencing technologies have become essential in studies on genomics,
epigenomics, and transcriptomics. Although sequencing information has traditionally been …
epigenomics, and transcriptomics. Although sequencing information has traditionally been …
Genomic analyses implicate noncoding de novo variants in congenital heart disease
A genetic etiology is identified for one-third of patients with congenital heart disease (CHD),
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …
Negative regulation of ABA signaling by WRKY33 is critical for Arabidopsis immunity towards Botrytis cinerea 2100
S Liu, B Kracher, J Ziegler, RP Birkenbihl, IE Somssich - elife, 2015 - elifesciences.org
The Arabidopsis mutant wrky33 is highly susceptible to Botrytis cinerea. We identified> 1680
Botrytis-induced WRKY33 binding sites associated with 1576 Arabidopsis genes …
Botrytis-induced WRKY33 binding sites associated with 1576 Arabidopsis genes …
PRDM16 is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle
Background: Left ventricular noncompaction cardiomyopathy (LVNC) was discovered half a
century ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall. In …
century ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall. In …
Complex interdependence regulates heterotypic transcription factor distribution and coordinates cardiogenesis
Transcription factors (TFs) are thought to function with partners to achieve specificity and
precise quantitative outputs. In the developing heart, heterotypic TF interactions, such as …
precise quantitative outputs. In the developing heart, heterotypic TF interactions, such as …
A promoter interaction map for cardiovascular disease genetics
Over 500 genetic loci have been associated with risk of cardiovascular diseases (CVDs);
however, most loci are located in gene-distal non-coding regions and their target genes are …
however, most loci are located in gene-distal non-coding regions and their target genes are …
A common genetic variant within SCN10A modulates cardiac SCN5A expression
M Van Den Boogaard, S Smemo… - The Journal of …, 2014 - Am Soc Clin Investig
Variants in SCN10A, which encodes a voltage-gated sodium channel, are associated with
alterations of cardiac conduction parameters and the cardiac rhythm disorder Brugada …
alterations of cardiac conduction parameters and the cardiac rhythm disorder Brugada …
iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy
K Kodo, SG Ong, F Jahanbani, V Termglinchan… - Nature cell …, 2016 - nature.com
Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in
children and its pathogenesis has been associated with the developmental defect of the …
children and its pathogenesis has been associated with the developmental defect of the …
Overexpression of Tbx20 in adult cardiomyocytes promotes proliferation and improves cardiac function after myocardial infarction
Background—Adult mammalian cardiomyocytes (CMs) have the potential to proliferate, but
this is not sufficient to generate adequate CMs after myocardial infarction (MI). The …
this is not sufficient to generate adequate CMs after myocardial infarction (MI). The …