Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

Role of glutathione in cancer: from mechanisms to therapies

L Kennedy, JK Sandhu, ME Harper, M Cuperlovic-Culf - Biomolecules, 2020 - mdpi.com
Glutathione (GSH) is the most abundant non-protein thiol present at millimolar
concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a …

Changes in glutathione content in liver diseases: an update

M Vairetti, LG Di Pasqua, M Cagna, P Richelmi… - Antioxidants, 2021 - mdpi.com
Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) …

P Kumar, O Osahon, DB Vides, N Hanania, CG Minard… - Antioxidants, 2021 - mdpi.com
Humanity is battling a respiratory pandemic pneumonia named COVID-19 which has
resulted in millions of hospitalizations and deaths. COVID-19 exacerbations occur in waves …

[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation

CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

Cellular compartmentalization, glutathione transport and its relevance in some pathologies

H Vázquez-Meza, MM Vilchis-Landeros… - Antioxidants, 2023 - mdpi.com
Reduced glutathione (GSH) is the most abundant non-protein endogenous thiol. It is a
ubiquitous molecule produced in most organs, but its synthesis is predominantly in the liver …

[HTML][HTML] SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione

D Bartolini, AM Stabile, S Bastianelli, D Giustarini… - Redox biology, 2021 - Elsevier
Viral infections sustain their replication cycle promoting a pro-oxidant environment in the
host cell. In this context, specific alterations of the levels and homeostatic function of the …

Targeting glutathione metabolism: partner in crime in anticancer therapy

E Desideri, F Ciccarone, MR Ciriolo - Nutrients, 2019 - mdpi.com
Glutathione (GSH) is the predominant low-molecular-weight antioxidant with a ubiquitous
distribution inside the cell. The steady-state level of cellular GSH is dependent on the …

[HTML][HTML] Nebulized glutathione as a key antioxidant for the treatment of oxidative stress in neurodegenerative conditions

JV Lana, A Rios, R Takeyama, N Santos, L Pires… - Nutrients, 2024 - mdpi.com
Glutathione (GSH), a tripeptide synthesized intracellularly, serves as a pivotal antioxidant,
neutralizing reactive oxygen species (ROS) and reactive nitrogen species (RNS) while …

Ferroptosis-related small-molecule compounds in cancer therapy: strategies and applications

L Yin, P Liu, Y Jin, Z Ning, Y Yang, H Gao - European Journal of Medicinal …, 2022 - Elsevier
Ferroptosis is a novel type of regulated cell death which is driven by iron-dependent lipid
peroxidation and subsequent plasma membrane ruptures. Since ferroptosis was coined …