Despite successful clot retrieval in large vessel occlusion stroke,∼ 50% of patients have an
unfavorable clinical outcome. The mechanisms underlying this functional reperfusion failure …

The integrity of myelinated axons relies on homeostatic support from oligodendrocytes
(OLs). To determine how OLs detect axonal spiking and how rapid axon–OL metabolic …

Investigating lactate dynamics in brain tissue is challenging, partly because in vivo data at
cellular resolution are not available. We monitored lactate in cortical astrocytes and neurons …

Orexins (also called hypocretins) are hypothalamic neuropeptides that carry out essential
functions in the central nervous system; however, little is known about their release and …

The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and
memory are still poorly explored. Astrocytes form large intercellular networks by gap junction …

Brain tissue metabolism is distributed across several cell types and subcellular
compartments, which activate at different times and with different temporal patterns. The …

Astrocytes establish extensive networks via gap junctions that allow each astrocyte to
connect indirectly to the vasculature. However, the proportion of astrocytes directly …

Sensory stimulation evokes intracellular calcium signals in astrocytes; however, the timing of
these signals is disputed. Here, we used novel combinations of genetically encoded calcium …

The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …

It has been suggested that, in states of arousal, release of noradrenaline and β-adrenergic
signalling affect long-term memory formation by stimulating astrocytic lactate production from …