Ionic liquids: new forms of active pharmaceutical ingredients with unique, tunable properties

JL Shamshina, RD Rogers - Chemical Reviews, 2023 - ACS Publications
This Review aims to summarize advances over the last 15 years in the development of
active pharmaceutical ingredient ionic liquids (API-ILs), which make up a prospective game …

Biocompatible ionic liquids and their applications in pharmaceutics

RM Moshikur, MR Chowdhury, M Moniruzzaman… - Green …, 2020 - pubs.rsc.org
Ionic liquids (ILs) have been used as solvents or materials, or both, in many applications,
including pharmaceutics and medicine due to their exceptional properties consisting of the …

Ionic liquids as a useful tool for tailoring active pharmaceutical ingredients

X Wu, Q Zhu, Z Chen, W Wu, Y Lu, J Qi - Journal of Controlled Release, 2021 - Elsevier
Ionic liquids (ILs) have been widely used in biomedical and pharmaceutical fields as
solvents or permeation enhancers. Recently, more and more researchers focused on …

Ionic liquids for enhanced drug delivery: recent progress and prevailing challenges

C Liu, B Chen, W Shi, W Huang… - Molecular Pharmaceutics, 2022 - ACS Publications
Ionic liquids (ILs) are a class of nonmolecular compounds composed only of ions.
Compared with traditional organic solvents, ILs have the advantages of wide chemical …

Recent advances in biocompatible ionic liquids in drug formulation and delivery

RM Moshikur, RL Carrier, M Moniruzzaman, M Goto - Pharmaceutics, 2023 - mdpi.com
The development of effective drug formulations and delivery systems for newly developed or
marketed drug molecules remains a significant challenge. These drugs can exhibit …

Active pharmaceutical ingredients (APIs) in ionic liquids: An effective approach for API physiochemical parameter optimization

M Handa, WH Almalki, R Shukla, O Afzal… - Drug Discovery …, 2022 - Elsevier
Highlights•Ionic liquids (ILs) are ions-based substances with melting points below 100
C.•Versatile nature and properties of ILs made it as solvent and designer …

Ionic liquids: Formulation avenues, drug delivery and therapeutic updates

NR Jadhav, SP Bhosale, SS Bhosale, SD Mali… - Journal of Drug Delivery …, 2021 - Elsevier
Background Numerous challenges are faced during formulation and biopharmaceutics of
newly developed drug molecules due to polymorphic conversion, poor bioavailability …

Application of design of experiments in the development of self-microemulsifying drug delivery systems

CM Hsieh, TL Yang, AD Putri, CT Chen - Pharmaceuticals, 2023 - mdpi.com
Oral delivery has become the route of choice among all other types of drug administrations.
However, typical chronic disease drugs are often poorly water-soluble, have low dissolution …

Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids

A Gamboa, N Schüßler, E Soto-Bustamante… - European Journal of …, 2020 - Elsevier
New therapeutics such as antisense oligonucleotides, small interfering RNA and peptide-
drug conjugates are taking great relevance in the pharmaceutical industry due to their …

Recent approaches of matrix release tablet in NDDS system

S Shekhar, A Kumar, V Rana, R Kumar, C Mittal… - Journal for Research in …, 2023 - jrasb.com
The purpose of this analysis is to categorize matrix tablets according to the kind of polymer
they are made of as well as the rate at which they release their contents. When it came to …