Tight junctions (TJ) play a central role in the homeostasis of epithelial and endothelial
tissues, by providing a semipermeable barrier to ions and solutes, by contributing to the …

The 'A Disintegrin And Metalloproteinase 10'(ADAM10) has gained considerable attention
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …

The endopeptidase ADAM10 is a critical catalyst for the regulated proteolysis of key drivers
of mammalian development, physiology, and non-amyloidogenic cleavage of APP as the …

The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …

Tight and adherens junctions are specialized sites of cell-cell interaction in epithelia and
endothelia, and are involved in barrier, adhesion, and signaling functions. These functions …

The ubiquitously expressed transmembrane protein a disintegrin and metalloproteinase 10
(ADAM10) functions as a “molecular scissor”, by cleaving the extracellular regions from its …

Intercellular contacts between epithelial cells are established and maintained by the apical
junctional complexes (AJCs). AJCs conserve cell polarity and build epithelial barriers to …

Transmembrane proteins of adherens and tight junctions are known targets for viruses and
bacterial toxins. The coronavirus receptor ACE2 has been localized at the apical surface of …

The brain is arguably the most fascinating and complex organ in the human body.
Recreating the brain in vitro is an ambition restricted by our limited understanding of its …

Paracingulin (CGNL1) is recruited to tight junctions (TJs) by ZO-1 and to adherens junctions
(AJs) by PLEKHA7. PLEKHA7 has been reported to bind to the microtubule minus-end …