Pharmacological modulation of the crosstalk between aberrant Janus kinase signaling and epigenetic modifiers of the histone deacetylase family to treat cancer

AHM Mustafa, OH Krämer - Pharmacological Reviews, 2023 - ASPET
Hyperactivated Janus kinase (JAK) signaling is an appreciated drug target in human
cancers. Numerous mutant JAK molecules as well as inherent and acquired drug resistance …

Extracellular vesicles from Listeria monocytogenes-infected dendritic cells alert the innate immune response

R Izquierdo-Serrano, I Fernández-Delgado… - Frontiers in …, 2022 - frontiersin.org
Communication through cell-cell contacts and extracellular vesicles (EVs) enables immune
cells to coordinate their responses against diverse types of pathogens. The function exerted …

DUALISTIC SAHA DOSE-DEPENDENT EFFECTS ON GLIAL-INFLAMMATORY RESPONSE

S Mancino Jr, M Boraso, A Galmozzi III… - bioRxiv, 2024 - biorxiv.org
Neuroinflammation comprises biochemical and cellular responses of the nervous system to
injury, emerging as a central process in many neurological conditions. Although beneficial in …