Brain, a subtle organ of multifarious nature presents plethora of physiological, metabolic and
bio-chemical convolutions that impede the delivery of biomolecules and thereby resulting in …

This review aims to cement three hot topics in drug delivery:(a) the pre-formulation of new
products intended for nose-to-brain delivery;(b) the development of nasal casts for studying …

Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options
for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions …

Vaccines are a very important tool in the effort to reduce the global burden of infectious
diseases. Modern vaccines can be formulated in several ways to induce specific immunity …

The nasal route has been investigated as a promising alternative for drug delivery to the
central nervous system, avoiding passage through the blood–brain barrier and improving …

Spray atomization process involves complex multi-phase phenomena. Abundant literature
and validation of spray modeling for industrial applications like fuel injection in internal …

Introduction This work aimed to develop chitosan-coated cubosomal nanoparticles intended
for nose-to-brain delivery of paliperidone palmitate. They were compared with standard and …

Nasal sprays, which produce relatively large pharmaceutical droplets and have high
momentum, are primarily used to deliver locally acting drugs to the nasal mucosa …

Effective pulmonary drug delivery through pressurized-metered dose inhalers (pMDIs)
depends on accurately targeting pharmaceutical aerosols to specific lung areas. Achieving …

Chronic rhinosinusitis is a common disease worldwide, and the frequently prescribed nasal
sprays do not sufficiently deliver the topical medications to the target sites so that the final …