As excessive sun exposure is tightly associated with different pathological changes of the
skin, for example premature skin ageing or the development of skin cancer, an appropriate …

The discovery of the BRAFV600E mutation led to the development of vemurafenib
(PLX4032), a selective BRAF inhibitor specific to the kinase, for the treatment of metastatic …

Responses of melanocytes (MC) to ultraviolet (UV) irradiation can be influenced by their
neighbouring keratinocytes (KC). We investigated the role of Nrf2 in regulating paracrine …

Ultraviolet radiation (UVR) is a very prominent environmental toxic agent. UVR has been
implicated in the initiation and progression of photocarcinogenesis. UVR exposure elicits …

Melanogenesis is the physiological process by which melanin is synthesized to protect the
skin from UV damage. While paracrine interactions between keratinocytes and melanocytes …

The photoadaptive responses of macroalgal communities to abiotic stresses have been
studied, and a number of UV-absorbing molecules have been identified. Among these …

Background Ultraviolet (UV) radiation constitutes an important risk factor for malignant
melanoma, but the wavelength responsible for the initiation of this disease is not fully …

Melanoma is an aggressive form of skin cancer refractory to conventional therapies. Obesity
has reached epidemic dimensions acting as a risk factor for several cancer types, such as …

Background: Anisomycin, a potential anticancer therapeutic drug, exerts an antitumor effect
on melanoma cells at a lower concentration than that required for other cancer cells …

Ultraviolet radiation (UVR) plays an important a role in melanmaogenesis. This may occur
by inducing reactive oxygen species (ROS) formation in melanocytes however, antioxidants …