Heparin-induced thrombocytopenia
A Greinacher - New England Journal of Medicine, 2015 - Mass Medical Soc
Key Clinical Points Heparin-Induced Thrombocytopenia Heparin-induced thrombocytopenia
(HIT) is characterized by a decrease in the platelet count of more than 50% from the highest …
(HIT) is characterized by a decrease in the platelet count of more than 50% from the highest …
Heparin-induced thrombocytopenia: pathogenesis and management.
TE Warkentin - British journal of haematology, 2003 - search.ebscohost.com
Review Page 1 Review HEPARIN-INDUCED THROMBOCYTOPENIA: PATHOGENESIS AND
MANAGEMENT Heparin-induced thrombocytopenia (HIT) is a transient prothrombotic disorder …
MANAGEMENT Heparin-induced thrombocytopenia (HIT) is a transient prothrombotic disorder …
Delayed-onset heparin-induced thrombocytopenia and thrombosis
TE Warkentin, JG Kelton - Annals of internal medicine, 2001 - acpjournals.org
Background: Heparin-induced thrombocytopenia is a prothrombotic drug reaction caused by
platelet-activating antibodies that recognize complexes of platelet factor 4 and heparin …
platelet-activating antibodies that recognize complexes of platelet factor 4 and heparin …
[HTML][HTML] Platelet-activating anti-PF4 disorders: an overview
TE Warkentin - Seminars in hematology, 2022 - Elsevier
Abstract Platelet factor 4 (PF4) is a highly cationic tetrameric protein that can be targeted by
platelet-activating anti-PF4 antibodies of immunoglobulin G (IgG) class. Certain features of …
platelet-activating anti-PF4 antibodies of immunoglobulin G (IgG) class. Certain features of …
Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia and thrombosis (HITT) is a severe complication of
heparin therapy caused by antibodies to complexes between unfractionated heparin (UFH) …
heparin therapy caused by antibodies to complexes between unfractionated heparin (UFH) …
Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcγRIIA
MP Reilly, SM Taylor, NK Hartman… - Blood, The Journal …, 2001 - ashpublications.org
Heparin-induced thrombocytopenia/thrombosis (HIT/HITT) is a severe, life-threatening
complication that occurs in 1% to 3% of patients exposed to heparin. Interactions between …
complication that occurs in 1% to 3% of patients exposed to heparin. Interactions between …
Heparin-induced thrombocytopenia: a historical perspective
JG Kelton, TE Warkentin - Blood, The Journal of the American …, 2008 - ashpublications.org
Heparin was discovered 90 years ago, 1 and within 2 decades it was being widely used as
an anticoagulant. 2 The numerous advantages of heparin lend to its broad use including its …
an anticoagulant. 2 The numerous advantages of heparin lend to its broad use including its …
Atomic description of the immune complex involved in heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is an autoimmune thrombotic disorder caused by
immune complexes containing platelet factor 4 (PF4), antibodies to PF4 and heparin or …
immune complexes containing platelet factor 4 (PF4), antibodies to PF4 and heparin or …
Platelet factor 4 triggers thrombo‐inflammation by bridging innate and adaptive immunity
A Greinacher, TE Warkentin - International Journal of …, 2023 - Wiley Online Library
Abstract Platelet factor 4 (PF4, synonym: CXCL4) is an evolutionary old chemokine with
proposed roles in hemostasis and antimicrobial defense. In addition, PF4 has attracted …
proposed roles in hemostasis and antimicrobial defense. In addition, PF4 has attracted …
Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome
TE Warkentin, WC Aird, JH Rand - ASH Education Program …, 2003 - ashpublications.org
Acquired abnormalities in platelets, endothelium, and their interaction occur in sepsis,
immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome …
immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome …