Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due
to complications of cirrhosis and 1 million due to viral hepatitis and hepatocellular …

Primary biliary cholangitis is an autoimmune liver disease that predominantly affects women.
It is characterised by a chronic and destructive, small bile duct, granulomatous lymphocytic …

Background Primary biliary cholangitis is a rare, chronic cholestatic liver disease
characterized by the destruction of interlobular bile ducts, leading to cholestasis and liver …

Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …

Non-invasive tests are increasingly being used to improve the diagnosis and
prognostication of chronic liver diseases across aetiologies. Herein, we provide the latest …

Background Effective treatments for patients with primary biliary cholangitis are limited.
Seladelpar, a peroxisome proliferator–activated receptor delta agonist, has potential …

Management of primary or secondary sclerosing cholangitis is challenging. These Clinical
Practice Guidelines have been developed to provide practical guidance on debated topics …

Background Histologically assessed liver fibrosis stage has prognostic significance in
patients with non-alcoholic fatty liver disease (NAFLD) and is accepted as a surrogate …

Cholestatic and non-alcoholic fatty liver disease (NAFLD) share several key
pathophysiological mechanisms which can be targeted by novel therapeutic concepts that …

Background Patients with primary biliary cholangitis who have an inadequate response to
therapy with ursodeoxycholic acid are at high risk for disease progression. Fibrates, which …