Individuals with Down syndrome present many clinical characteristics, such as metabolic,
endocrine, anatomic and neurologic dysfunctions, that contribute to the physiopathology of …

OBJECTIVE To explore the effects of empagliflozin on the incidence of obstructive sleep
apnea (OSA) and its effects on metabolic, cardiovascular (CV), and renal outcomes among …

Purpose Clozapine is an antipsychotic which was approved in 1989 for treatment-resistant
schizophrenia in the United States (US). There were few randomized trials before its …

Aims: Obstructive sleep apnea (OSA) and insomnia commonly coexist; hypnotics are
broadly prescribed for insomnia therapy. However, the safety of hypnotics use in OSA …

Vitiligo is a common depigmenting disorder ensuing the loss of epidermal melanocytes. It is
a multifactorial disease with immunological, genetic and environmental factors including …

We aim to discover new safety signals of drug-induced sleep apnoea (SA), a global health
problem affecting approximately 1 billion people worldwide. We first conducted a series of …

Purpose Patients with psychiatric disorders often complain of sleep disturbances and are
frequently suspected of obstructive sleep apnea (OSA). However, data regarding sleep …

After experiencing a traumatic brain injury (TBI), the majority of patients will develop sleep–
wake disorders (SWD). These can include insomnia, pleiosomnia, excessive daytime …

Baclofen is a centrally acting gamma aminobutyric acid (GABA)-B agonist, widely used for
chronic spasticity in neurological disorders, available in oral and intrathecal formulations …

The interaction between certain drug classes and SDB is of clinical relevance for sleep
medicine. Specific patient populations with acute and chronic pain, chronic insomnia, or …