Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …

Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE)
pathway is an important cell signaling mechanism in maintaining redox homeostasis in …

Nrf2 acts as a sensor of oxidative or electrophilic stress and prevents genome instability. The
activation of Nrf2 signaling induces ARE-dependent expression of detoxifying and …

Neurological disorders represent a great challenge and are the leading cause of death and
disability globally. Although numerous complicated mechanisms are involved in the …

Ischemic stroke, characterized by the sudden loss of blood flow in specific area (s) of the
brain, is the leading cause of permanent disability and is among the leading causes of death …

The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an
efficient and pivotal line of defensive to counteract environmental insults and endogenous …

Ischemic disease is a class of diseases in which an organ is ischemic due to vascular
occlusion, a major contributor to death and disability worldwide. However, when the blood …

Significance: Sulforaphane, produced by the hydrolytic conversion of glucoraphanin after
ingestion of cruciferous vegetables, particularly broccoli and broccoli sprouts, has been …

Keap1/Nrf2 system plays a critical role on cellular protection by regulating many antioxidant
and detoxification enzyme genes through the antioxidant response element (ARE). Thus, it …