Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …

Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Stroke is the second leading cause of death, after ischemic heart disease, and accounts for
9% of deaths worldwide. According to the World Health Organization [WHO], 15 million …

Autophagy is the general term of lysosomal degradation of substances in cells, which is
considered the key to maintaining the normal structure and function of the heart. It also has a …

Diabetic cardiomyopathy (DCM) is often associated with suppressed cardiac autophagy,
mitochondrial structural and functional impairment. Sirtuin-3 (Sirt3) has been reported to …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

It has been established that the key metabolic pathways of glycolysis and oxidative
phosphorylation are intimately related to redox biology through control of cell signaling …

Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its
cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in …

Autophagy is a bulk degradation process in which cytosolic proteins and organelles are
degraded through lysosomes. To evaluate autophagic flux in cardiac myocytes, we …

Aims The present study was designed to examine the mechanism involved in mitochondrial
aldehyde dehydrogenase (ALDH2)-induced cardioprotection against ischaemia/reperfusion …